abstract：:Estrogen increases and progesterone decreases the acquisition and reinstatement of cocaine-seeking behavior in female rats. Here estrogen and progesterone were studied for their effects on the escalation of cocaine self-administration in female rats. The rats received ovariectomy (OVX) or sham (SH) surgery and were tr...

journal_title：Experimental and clinical psychopharmacology

authors： Larson EB,Anker JJ,Gliddon LA,Fons KS,Carroll ME

更新日期：2007-10-01 00:00:00

abstract：:Goods-based contingency management interventions (e.g., those using vouchers or prizes as incentives) have demonstrated efficacy in reducing cocaine use, but cost has limited dissemination to community clinics. Recent research suggests that development of a cash-based contingency management approach may improve treatm...

journal_title：Experimental and clinical psychopharmacology

authors： Vandrey R,Bigelow GE,Stitzer ML

更新日期：2007-08-01 00:00:00

abstract：:The present, subjective value of a reinforcer typically decreases as a function of the delay to its receipt, a phenomenon termed delay discounting. Delay discounting, which is assumed to reflect impulsivity, is hypothesized to play an important role in drug abuse. The present study examined delay discounting of cocain...

journal_title：Experimental and clinical psychopharmacology

authors： Woolverton WL,Myerson J,Green L

更新日期：2007-06-01 00:00:00

abstract：:Female inner-city substance users evidence greater crack/cocaine use and are more likely to be dependent on this drug than on any other drug. Additionally, female inner-city substance users evidence greater crack/cocaine use and are more likely to be dependent on this drug than their male counterparts, despite no cons...

journal_title：Experimental and clinical psychopharmacology

authors： Lejuez CW,Bornovalova MA,Reynolds EK,Daughters SB,Curtin JJ

更新日期：2007-04-01 00:00:00

abstract：:The effect of benzodiazepines on attention has been the object of few investigations. Studies using the spatial cueing paradigm (Posner's paradigm) have reported inconsistent results, which are likely due to methodological and/or dose differences but suggest impaired disengagement of attention from the cue to the targ...

journal_title：Experimental and clinical psychopharmacology

authors： Boucart M,Waucquier N,Michael GA,Libersa C

更新日期：2007-02-01 00:00:00

abstract：:Lapses within the first 2 weeks of a smoking cessation attempt are strongly associated with a return to regular smoking (S. L. Kenford et al., 1994). Unfortunately, little is known about how to prevent an initial lapse from progressing to a full relapse, and presently there are no validated lapse-responsive therapeuti...

journal_title：Experimental and clinical psychopharmacology

authors： Juliano LM,Houtsmuller EJ,Stitzer ML

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Despite increases in ecstasy (MDMA) use in the United States, little is known about characteristics linked with recent-onset ecstasy use, especially psychiatric symptoms and deviant behaviors. AIMS:To test whether individuals with high levels of other drug use are more likely to be recent-onset ecstasy user...

journal_title：Experimental and clinical psychopharmacology

authors： Martins SS,Mazzotti G,Chilcoat HD

更新日期：2006-08-01 00:00:00

abstract：:This study examined the association between the heart rate (HR) response to alcohol intoxication, which is thought to reflect sensitivity to alcohol-induced reward and alcohol-induced behavioral disinhibition. High- and low-HR responders to alcohol participated in a go/no-go task, under sober and intoxicated condition...

journal_title：Experimental and clinical psychopharmacology

authors： Assaad JM,Pihl RO,Séguin JR,Nagin DS,Vitaro F,Tremblay RE

更新日期：2006-08-01 00:00:00

abstract：:Maternal smoking is a leading preventable cause of poor pregnancy outcomes and infant morbidity and mortality. Whereas pregnancy has been thought of as a "window of opportunity" when women are more motivated to change health behaviors such as smoking, only 20% of pregnant women quit smoking upon learning they are preg...

journal_title：Experimental and clinical psychopharmacology

authors： Heil SH,Higgins ST,Mongeon JA,Badger GJ,Bernstein IM

更新日期：2006-05-01 00:00:00

abstract：:In community-based alcoholism and drug abuse treatment programs, the vast majority of interventions are delivered in a group therapy context. In turn, treatment providers and funding agencies have called for more research on interventions delivered in groups in an effort to make the emerging empirical literature on th...

journal_title：Experimental and clinical psychopharmacology

authors： Morgan-Lopez AA,Fals-Stewart W

更新日期：2006-05-01 00:00:00

abstract：:It is becoming increasingly evident that the sex of an organism is a critical determinant of responsiveness to opioid analgesics. However, the factors that determine the magnitude and direction of sex differences in opioid antinociception have not been fully elucidated. One factor that has received attention is the re...

journal_title：Experimental and clinical psychopharmacology

authors： Barrett AC

更新日期：2006-02-01 00:00:00

abstract：:This study examined prevalence and patterns of co-use of opioids and cocaine in regular users of illicit opioids (N = 729) recruited from 5 Canadian cities. Fifty-seven percent (n = 417) reported having used both opioids and cocaine in the month and week preceding the interview; of these, 73% (n = 304) were able to id...

journal_title：Experimental and clinical psychopharmacology

authors： Leri F,Stewart J,Fischer B,Jürgen R,Marsh DC,Brissette S,Bruneau J,El-Guebaly N,Noël L,Tyndall MW,Wild TC

更新日期：2005-11-01 00:00:00

abstract：:The review article "Regulation of Drug Taking by Sensitization and Habituation" by F. K. McSweeney, E. S. Murphy, and B. P. Kowal introduces 2 basic principles of behavior, sensitization and habituation, into a comprehensive model for studying drug intake and drug addiction. A key assumption of the model is that the r...

journal_title：Experimental and clinical psychopharmacology

authors： Rowlett JK

更新日期：2005-08-01 00:00:00

abstract：:The consumption of caffeine has become a growing concern, partially because of the withdrawal properties of the drug. The current study examined personality correlates of caffeine consumption and dependence in 60 university students. Self-report and behavioral measures of sensation seeking, impulsivity, and risk takin...

journal_title：Experimental and clinical psychopharmacology

authors： Jones HA,Lejuez CW

更新日期：2005-08-01 00:00:00

abstract：:Two groups of male Japanese quail (Coturnix japonica) were trained [corrected] to discriminate cocaine from saline in a conditioned approach procedure maintained by sexual reinforcement. For 1 group, cocaine (10 mg/kg ip) was administered prior to a conditioned stimulus (CS) that predicted copulation; saline followed ...

journal_title：Experimental and clinical psychopharmacology

authors： Troisi JR 2nd,Akins C

更新日期：2004-11-01 00:00:00

abstract：:The effects of methylphenidate (MPH) on performance of a time-production task were studied in 17 children with attention-deficit/hyperactivity disorder who participated in 1 test session on and 1 off MPH. Participants held a response lever down for at least 10 but no longer than 14 s. Administration of MPH had no effe...

journal_title：Experimental and clinical psychopharmacology

authors： Baldwin RL,Chelonis JJ,Flake RA,Edwards MC,Feild CR,Meaux JB,Paule MG

更新日期：2004-02-01 00:00:00

abstract：:Nonpharmacological cues associated with drug intake may influence subjective and reinforcing effects of those drugs. Social drinkers (N = 80) participated in 2 sessions in which they rated and then consumed ad lib their preferred beer (with participants blind to brand). Visual and olfactory stimuli were obscured durin...

journal_title：Experimental and clinical psychopharmacology

authors： Perkins KA,Ciccocioppo M,Jacobs L,Doyle T,Caggiula A

更新日期：2003-11-01 00:00:00

abstract：:The present study explores the relation among 4 personality traits associated with impulsive behavior and alcohol abuse. Personality traits were measured using the 4 subscales of the UPPS Impulsive Behavior Scale (UPPS; S. P. Whiteside & D. R. Lynam, 2001). The UPPS and measures of psychopathology were administered to...

journal_title：Experimental and clinical psychopharmacology

authors： Whiteside SP,Lynam DR

更新日期：2003-08-01 00:00:00

abstract：:Some sons of male alcoholics (SOMAs) are characterized by an increased heart rate (HR) response to alcohol intoxication, which is thought to reflect increased sensitivity to alcohol-induced reward. Such a response has also been related to increased physical aggression. However, the confounding effect of aggression in ...

journal_title：Experimental and clinical psychopharmacology

authors： Assaad JM,Pihl RO,Séguin JR,Nagin D,Vitaro F,Carbonneau R,Tremblay RE

更新日期：2003-05-01 00:00:00

abstract：:In this study, crack/cocaine-dependent (CD) and non-drug-using matched control (MC) participants were presented with hypothetical immediate and delayed rewards, with 16 delay conditions ranging from 5 min to 25 years. All participants were presented with hypothetical monetary rewards; however, the CD group was also pr...

journal_title：Experimental and clinical psychopharmacology

authors： Coffey SF,Gudleski GD,Saladin ME,Brady KT

更新日期：2003-02-01 00:00:00

abstract：:In an elegant series of experiments, F. Leri and J. Stewart (2002) report that exposure to heroin increases subsequent reinstatement responding if the animal has access to the drug lever during the lapse and if responding on the lever results in the presentation of conditioned cues. It is interesting that exposure to ...

journal_title：Experimental and clinical psychopharmacology

authors： Goeders NE

更新日期：2002-11-01 00:00:00

abstract：:This study examined the relation of the Five-Factor Model (FFM) of personality to symptoms of alcohol and marijuana abuse before and after controlling for symptoms of antisocial personality disorder (APD) and internalizing psychopathology. The 481 participants completed a well-validated measure of the FFM and a struct...

journal_title：Experimental and clinical psychopharmacology

authors： Flory K,Lynam D,Milich R,Leukefeld C,Clayton R

更新日期：2002-11-01 00:00:00

abstract：:Substance use disorders and pathological gambling share similarities in terms of diagnostic criteria, epidemiology, and clinical course. However, relatively few studies have evaluated the efficacy of treatments for gambling disorders. As interest in pathological gambling grows, adaptation of effective treatments from ...

journal_title：Experimental and clinical psychopharmacology

authors： Petry NM

更新日期：2002-08-01 00:00:00

abstract：:Using data from 4 smoking cessation trials conducted from 1988 to 2000, the authors investigated whether men are more successful than women in quitting smoking. Odds ratios indicated that the abstinence rates were not significantly different for men and women. Thus, there may be little value to diverting research fund...

journal_title：Experimental and clinical psychopharmacology

authors： Killen JD,Fortmann SP,Varady A,Kraemer HC

更新日期：2002-08-01 00:00:00

abstract：:It is proposed that potential drug cues are evaluated preattentively, are prioritized, and subsequently trigger somatovisceral, behavioral, and cognitive responses. Throughout, this information processing is subjected to automatized attentional and interpretative biases. These processes can enhance subjective awarenes...

journal_title：Experimental and clinical psychopharmacology

authors： Ryan F

更新日期：2002-05-01 00:00:00

abstract：:In this experiment, the observing-response procedure was adapted for use with drug self-administration. Rats' responding for oral ethanol was sometimes reinforced on a random-ratio schedule, whereas at other times it had no effect (i.e., extinction). Behavior producing stimuli associated with the otherwise unsignaled ...

journal_title：Experimental and clinical psychopharmacology

authors： Shahan TA

更新日期：2002-02-01 00:00:00

abstract：:The authors investigated several features of polydrug use in rats. Heroin and cocaine were self-administered following responses on different levers, with only 1 drug and 1 lever available on alternate days of training. Four doses of each drug (heroin: 25, 50, 100, and 200 microg/kg/infusion; cocaine: 0.25, 0.5, 1, an...

journal_title：Experimental and clinical psychopharmacology

authors： Leri F,Stewart J

更新日期：2001-08-01 00:00:00

abstract：:W. J. Lynch and M. E. Carroll (2001) suggested 3 processes that contribute to the regulation of drug intake over time when drugs serve as reinforcers. The commentator suggests that none of these processes are necessary for drugs to function as reinforcers and hence are either secondary or superfluous to the study of d...

journal_title：Experimental and clinical psychopharmacology

authors： Woods JH

更新日期：2001-05-01 00:00:00

abstract：:Six features of the report are commented on. First, the Therapeutic Workplace intervention described in the report represents a creative and promising new approach to drug abuse treatment. Second, to the author's knowledge, it represents the first intervention that has been shown in a randomized clinical trial to sign...

journal_title：Experimental and clinical psychopharmacology

authors： Higgins ST

更新日期：2001-02-01 00:00:00

abstract：:Although marijuana is the most commonly used illicit drug in the United States, it is not established whether withdrawal from chronic use results in a clinically significant abstinence syndrome. The present study was conducted to characterize symptoms associated with marijuana withdrawal following chronic use during a...

journal_title：Experimental and clinical psychopharmacology

authors： Kouri EM,Pope HG Jr

更新日期：2000-11-01 00:00:00

abstract：:P. R. Giancola's (2000) macroconstruct framework of executive functions (EF) characterizes how cognitive processes work together to inhibit aggressive responding in provocative situations, and how alcohol intoxication increases the likelihood of aggression by disrupting these processes. His framework can be considered...

journal_title：Experimental and clinical psychopharmacology

authors： Bates ME

更新日期：2000-11-01 00:00:00

abstract：:This review outlines the development and use of placebo cigarettes in smoking research. Research on effects of smoking has been disadvantaged by the lack of an adequate placebo condition. Recently, tobacco-based denicotinized cigarettes have been used in smoking research to distinguish effects of smoking due to the de...

journal_title：Experimental and clinical psychopharmacology

authors： Robinson ML,Houtsmuller EJ,Moolchan ET,Pickworth WB

更新日期：2000-08-01 00:00:00

abstract：:This study shows that a moderate dose of alcohol (0.62 g/kg) can impair cognitive processes controlling behavioral inhibition and flexibility (i.e., inhibiting one response and making a different one). Two groups of male social drinkers (n = 8) received alcohol or a placebo and performed two change tasks that required...

journal_title：Experimental and clinical psychopharmacology

authors： Easdon CM,Vogel-Sprott M

更新日期：2000-08-01 00:00:00

abstract：:This study targeted poly-drug (cocaine plus heroin) abstinence among buprenorphine-maintained participants with a 12-week voucher-based reinforcement therapy (VBRT) phase versus a yoked control condition. Baseline levels of cocaine and heroin use were significant predictors of treatment outcome, regardless of treatmen...

journal_title：Experimental and clinical psychopharmacology

authors： Downey KK,Helmus TC,Schuster CR

更新日期：2000-05-01 00:00:00

abstract：:Nicotine administration has been found to enhance performance on tasks of selective attention. It has been proposed that efficient attentional filtering depends on the successful inhibition of distracting information. In the work reported here, a negative priming paradigm was adopted to test whether smoking enhanced t...

journal_title：Experimental and clinical psychopharmacology

authors： Rodway P,Dienes Z,Schepman A

更新日期：2000-02-01 00:00:00

abstract：:When 2 stimuli that occasion cocaine self-administration are presented in compound, their ability to increase cocaine-reinforced operant responding is substantially enhanced. The goal of the present experiment was to determine whether stimulus compounding could produce analogous enhancements of a classically condition...

journal_title：Experimental and clinical psychopharmacology

authors： Panlilio LV,Weiss SJ,Schindler CW

更新日期：2000-02-01 00:00:00

abstract：:The accurate assessment of nicotine withdrawal is important theoretically and clinically. A 28-item scale, the Wisconsin Smoking Withdrawal Scale, was developed that contains 7 reliable subscales tapping the major symptom elements of the nicotine withdrawal syndrome. Coefficients alpha for the subscales range from .75...

journal_title：Experimental and clinical psychopharmacology

authors： Welsch SK,Smith SS,Wetter DW,Jorenby DE,Fiore MC,Baker TB

更新日期：1999-11-01 00:00:00

abstract：:Two studies were conducted to determine the anger-attenuating effects of nicotine as a function of trait hostility. The 1st study examined the effects of nicotine on diary ratings of anger during a 24-hr period in a natural setting in 30 smokers and 30 nonsmokers. Participants took part in 2 monitoring sessions involv...

journal_title：Experimental and clinical psychopharmacology

authors： Jamner LD,Shapiro D,Jarvik ME

更新日期：1999-11-01 00:00:00

abstract：:Heavy smokers (N = 408, smoking more than 25 cigarettes/day) were randomized to receive high-dose (25 mg) or standard-dose (15 mg) nicotine patch therapy delivered during the daytime only (16 hr) for a period of 6 weeks. Treatment effects of each dose were similar. The percentages of participants not smoking at 2-, 6-...

journal_title：Experimental and clinical psychopharmacology

authors： Killen JD,Fortmann SP,Davis L,Strausberg L,Varady A

更新日期：1999-08-01 00:00:00

abstract：:Rats were exposed to a diet containing 100 ppm cadmium chloride or a control diet. At 52 days of exposure, rats were trained to discriminate between saline and 5 mg/kg cocaine injections. After acquisition training, successive substitution tests were conducted using cocaine, the indirect dopamine agonist d-amphetamine...

journal_title：Experimental and clinical psychopharmacology

authors： Nation JR,Miller DK

更新日期：1999-05-01 00:00:00